active placebo
A researcher administers an active placebo to a participant in a clinical trial.
Noun: A type of placebo used in clinical trials that produces noticeable physical effects, allowing it to mimic the side effects of the actual experimental drug being tested. This design helps to maintain the "blind" in a blinded study by ensuring that participants cannot guess whether they are receiving the real treatment or the placebo based solely on the presence or absence of side effects.
The term is used primarily in medical, pharmacological, and psychological research contexts to describe a control substance in an experiment. - It is a compound noun where "active" modifies "placebo" to specify a particular kind of placebo with physiological effects. - It is typically used as a countable noun (e.g., an active placebo, the active placebo).
- The study used an active placebo that caused a dry mouth, which was a known side effect of the real antidepressant.
- To ensure the trial was double-blind, researchers administered either the new drug or an active placebo that mimicked its minor side effects.
- Participants who received the active placebo reported similar physical sensations to those who received the experimental treatment.
- Methodological Role: The use of an active placebo is considered a more rigorous control condition than an inert placebo (like a sugar pill) in trials for drugs with perceptible side effects. It helps control for the placebo effect for participant expectations based on experiencing side effects.
- Ethical Consideration: Its use is debated, as deliberately inducing side effects, even mild ones, in control groups raises ethical questions.
- Placebo (n): A substance or treatment with no therapeutic effect, used as a control in testing new drugs.
- Inert placebo (n): A placebo that has no physiological effects (e.g., a sugar pill, saline injection).
- Control group (n): The group in an experiment that receives the placebo or standard treatment, used for comparison.
- Nocebo effect (n): The phenomenon where a placebo causes harmful or unpleasant side effects due to negative expectations.
- Active control placebo
- Impure placebo (This term is less common and can be ambiguous.)
- Double-blind procedure: A research design where neither the participants nor the experimenters know who is receiving the active treatment and who is receiving the placebo or control. The active placebo is a tool to protect the integrity of this blind.
- Placebo-controlled trial: A study in which the experimental treatment is compared with a placebo. An placebo-controlled trial specifies the use of an active placebo.
A researcher administers an active placebo to a participant in a clinical trial.
- a placebo used in experimental tests of a drug that has noticeable side effects
- an active placebo mimics the side effects of the experimental drug